Tiny Universe: new paper on intracellular nanovesicles

We have a new paper out! You can access it here. The paper in a nutshell We have discovered a new class of trafficking vesicle inside cells. These vesicles are very small (30 nm across) and we’ve called them intracellular nanovesicles, or INVs for short. What is a trafficking vesicle? Humans are built from lots […]

Come To California

I’ve returned from the American Society for Cell Biology 2016 meeting in San Francisco. Despite being a cell biologist and people from my lab attending this meeting numerous times, this was my first ASCB meeting. The conference was amazing, so much excellent science and so many opportunities to meet up with people. For the areas that […]

The Digital Cell: Getting started with IgorPRO

This post follows on from “Getting Started“. In the lab we use IgorPRO for pretty much everything. We have many analysis routines that run in Igor, we have scripts for processing microscope metadata etc, and we use it for generating all figures for our papers. Even so, people in the lab engage with it to varying extents. The […]

The Digital Cell

If you are a cell biologist, you will have noticed the change in emphasis in our field. At one time, cell biology papers were – in the main – qualitative. Micrographs of “representative cells”, western blots of a “typical experiment”… This descriptive style gave way to more quantitative approaches, converting observations into numbers that could be objectively assessed. […]

What Can You See?

Yesterday I tried a gedankenexperiment via Twitter, and asked: If you could visualise a protein relative to an intracellular structure/organelle at ~5 nm resolution, which one would you pick and why? https://twitter.com/clathrin/status/707949738323218432 I got some interesting replies: Myosin Va and cargo on actin filaments in melanocytes – Cleidson Alves @cleidson_alves COPII components relative to ER […]