Clathrin is a three-legged protein complex or triskelion that can assemble into lattice-like structures. Inside the cell, this assembly helps to create vesicles: tiny packages of membranes containing proteins and goodies for the cell to use. Incredibly our first view of assembled clathrin was made in the 1960s, with resolution improving steadily since then. The […]
Author: quantixed
Os Mutantes: an implausible naming system for SARS-CoV-2 mutants
The scientific response to the COVID-19 pandemic has been astounding. Aside from efforts to generate vaccines, the genomic surveillance of the virus has been truly remarkable. For example, the nextstrain project has sequence many SARS-CoV-2 genomes. In fact, the rapid identification of multiple new strains and mutations by diverse groups of scientists has resulted in […]
You Better Run: recovering from injury
Reading about someone else’s recovery-after-injury story can be a bit dull. At least that was my conclusion after pressing delete on my story a moment ago. Having spared you the details, the summary is: I got injured. It hurt. It took me a year to recover because I didn’t tackle the recovery properly. Measuring recovery […]
Keep A Knockin: new paper using knock-in technology
We have a new paper out! I am a bit late with this post, since the accepted version went online in December 2020, and the final version appeared a few weeks ago. It will shortly appear in a finished issue of the journal so I can tell myself that I am not too late yet. […]
Target: monitoring a running goal in R
Many running races and events have been cancelled or disrupted due to the pandemic. To fill the void, I’ve been taking on Garmin’s “Challenges”. In Garmin Connect, you can accept a challenge set by Garmin (I think users can challenge each other too). Completion of these challenges gives the user points, which I’ve become somewhat […]
Crackerblocks: computing solutions for IQ Block game
The IQ Block game is a puzzle where the player must fit eight shapes into a square space. The challenge is to find as many ways as possible to do it. The box says there are more than 40 solutions! So how many are there? I wrote a solver to crack the IQ Block game. […]
I’ve Gotta Get A Message To You: automated emails from Raspberry Pi zero
I have a long-running project to make timelapse movies using a Raspberry Pi Zero with camera module. I’m capturing a countryside view and have images for two years. The uptime on the Pi is seriously impressive, but nonetheless I wanted to upgrade the Pi so that it would send me updates of how it’s going, […]
Methods papers for MD997 – 2021 Edition
It is an annual event on quantixed to post the papers I have selected for MD997 Frontier Techniques and Research Skills in Biomedicine. Previous selections are grouped here. The deal is that each student picks a paper from the list and then uses it to write a “grant application” for a research project. They also […]
Tips From The Blog XIV: embedded file locations in an Adobe Illustrator file
I was working on a figure in Adobe Illustrator today. The ai file had 32 embedded TIFF files (we tend to embed images rather than linking them for portability reasons). I wanted to change all of the images, but to do this I needed to know where the originals were. Clicking on the file shows […]
All My Trials: Impact of COVID-19 on rare disease clinical trials
The database clinicaltrials.gov is a web resource of clinical trials around the world. It has a REST API that gives access to clinical trial data. There are some resources available to interact with this resource using R, such as rclinicaltrials and ClinicalTrialsAPI. We were interested at looking clinical trials for rare diseases and particularly whether […]