Don’t Let Go The Coat: new paper on clathrin assembly

A new paper means a new paper explainer. This post is all about our new paper on clathrin assembly. Some background info Endocytosis is the way that cells take up material from the outside world. The cell can make tiny vesicles that bud inwards from the cell surface and pinch off to travel inside the […]

Start Me Up: Endocytosis on demand

We have a new paper out. The title is New tools for ‘hot-wiring’ clathrin-mediated endocytosis with temporal and spatial precision. You can read it here. Cells have a plasma membrane which is the barrier between the cell’s interior and the outside world. In order to import material from outside, cells have a special process called […]

Zero Tolerance

We were asked to write a Preview piece for Developmental Cell. Two interesting papers which deal with the insertion of amphipathic helices in membranes to influence membrane curvature during endocytosis were scheduled for publication and the journal wanted some “front matter” to promote them. Our Preview is paywalled – sorry about that – but I […]

Insane In The Brain

Back of the envelope calculations for this post. An old press release for a paper on endocytosis by Tom Kirchhausen contained this fascinating factoid: The equivalent of the entire brain, or a football field of membrane, is turned over every hour If this is true it is absolutely staggering. Let’s check it out. A synaptic […]

Outer Limits

This post is about a paper that was recently published. It was the result of a nice collaboration between me and Francisco López-Murcia and Artur Llobet in Barcelona. The paper in a nutshell The availability of clathrin sets a limit for presynaptic function Background Clathrin is a three legged protein that forms a cage around […]

Into The Great Wide Open

We have a new paper out! You can read it here. I thought I would write a post on how this paper came to be and also about our first proper experience with preprinting. Title of the paper: Non-specificity of Pitstop 2 in clathrin-mediated endocytosis. In a nutshell: we show that Pitstop 2, a supposedly selective clathrin […]