To validate our analyses, I’ve been using randomisation to show that the results we see would not arise due to chance. For example, the location of pixels in an image can be randomised and the analysis rerun to see if – for example – there is still colocalisation. A recent task meant randomising live cell […]

# Tag: statistics

## Parallel lines: new paper on modelling mitotic microtubules in 3D

We have a new paper out! You can access it here. The people This paper really was a team effort. Faye Nixon and Tom Honnor are joint-first authors. Faye did most of the experimental work in the final months of her PhD and Tom came up with the idea for the mathematical modelling and helped to […]

## Elevation: accuracy of a Garmin Edge 800 GPS device

I use a Garmin 800 GPS device to log my cycling activity. including my commutes. Since I have now built up nearly 4 years of cycling the same route, I had a good dataset to look at how accurate the device is. I wrote some code to import all of the rides tagged with commute […]

## The Digital Cell: Statistical tests

Statistical hypothesis testing, commonly referred to as “statistics”, is a topic of consternation among cell biologists. This is a short practical guide I put together for my lab. Hopefully it will be useful to others. Note that statistical hypothesis testing is a huge topic and one post cannot hope to cover everything that you need to […]

## The Digital Cell

If you are a cell biologist, you will have noticed the change in emphasis in our field. At one time, cell biology papers were – in the main – qualitative. Micrographs of “representative cells”, western blots of a “typical experiment”… This descriptive style gave way to more quantitative approaches, converting observations into numbers that could be objectively assessed. […]

## Adventures in code II

I needed to generate a uniform random distribution of points inside a circle and, later, a sphere. This is part of a bigger project, but the code to do this is kind of interesting. There were no solutions available for IgorPro, but stackexchange had plenty of examples in python and mathematica. There are many ways to do […]

## Weak Superhero: how to win and lose at Marvel Top Trumps

Top Trumps is a card game for children. The mind can wander when playing such games with kids… typically, I start thinking: what is the best strategy for this game? But also, as the game drags on: what is the quickest way to lose? Since Top Trumps is based on numerical values with simple outcomes, it seemed […]

## Repeat Failure: Crewe Alexandra F.C.

Well, the 2015/2016 season was one to forget for Crewe Alexandra. Relegation to League Two (English football’s 4th tier) was confirmed on 9th April with a 3-0 defeat to local rivals Port Vale. Painful. Maybe Repeat Failure is a bit strong. Under Dario Gradi, the Railwaymen eventually broke into League One/Championship (the 2nd Tier) where […]

## Wrote for Luck

Fans of probability love random processes. And lotteries are a great example of random number generation. The UK National Lottery ran in one format from 19/11/1994 until 7/10/2015. I was talking to somebody who had played the same set of numbers in all of these lottery draws and I wondered what the net gain or […]

## Lemonade Secret Drinker: sober statistics

I read this article on the BBC recently about alcohol consumption in the UK. In passing it mentions how many people in the UK are teetotal. I found the number reported – 21% – unbelievable so I checked out the source for the numbers. Sure enough, ~20% of the UK population are indeed teetotal (see […]